Dr. Christian Habeck
Columbia University
"Multivariate approaches to neuroimaging analysis 101"
Friday, November 2, 2007
2:00-3:00pm
SSPA 2112
Abstract
As the clinical and cognitive neurosciences mature, multivariate analysis techniques for neuroimaging data have received increasing attention since they possess some attractive features that cannot be easily realized by the more commonly used univariate, voxel-wise, techniques: (1) multivariate approaches evaluate correlation/covariance of activation across brain regions, rather than proceeding on a voxel-wise basis. Thus, their results can be more easily interpreted as a signature of neural networks. (2) Multivariate techniques also lend themselves better to prospective application of results obtained from the analysis of one dataset to entirely new datasets. Multivariate techniques are thus well placed to provide information about mean differences and correlations with behavior, similarly to univariate approaches, but with potentially greater statistical power and better reproducibility checks. Despite these attractive features, the barrier of entry to the use of multivariate approaches has been high, preventing more widespread application in the community. We have therefore proposed a series of studies comparing multivariate approaches amongst each other and with traditional univariate approaches in didactic reports and comprehensive review papers, using simulated as well as real-world data sets.
In my presentation, I will give a simple mathematical overview of univariate and multivariate approaches. Then I‚ll present two examples of multivariate analysis applied to: (1) an fMRI data set from a study using a delayed-response task, and (2) a clinical data set from a study comparing healthy elderly participants with early Alzheimer‚s disease patients, using resting scans of regional Cerebral Blood Flow. The presentation will close with remaining challenges and directions for the future.
Tuesday, October 30, 2007
Wednesday, October 24, 2007
2006-2007 CCNS Event Schedule
UC Irvine, Center for Cognitive Neuroscience
Event Calendar 2007-2008
Please note: The events and times on this calendar are subject to change throughout the year.
Wednesday, October 31, Richard Wise, University College London
1-2pm SSPA 22112
Friday, November 2 Chris Habeck, Columbia University Medical Center
2-3pm SSPA 2112
Friday, November 9 Chi-Hung Juan, National Central University, Taiwan
12-1pm, location TBA
Monday, November 19 Ed Awh, University of Oregon
4-5pm SSPA 2112
Friday, November 30 Quarterly Meeting
2-3pm SSPA 2112
Monday, December 3 Tatiana Pasterak, University of Rochester Medical Center
4-5pm SSPA 2112
Friday, January 25 Lunch Seminar
12-1pm, speaker and location TBA
Friday, February 8 Quarterly Meeting
2-3pm, location TBA
Friday, March 14 David Eagleman, Baylor College of Medicine
12-1pm Herklotz
Friday, April 18 Quarterly Meeting
2-3pm, location TBA
Friday, May 30 Lunch Seminar
12-1pm Speaker and location TBA
Event Calendar 2007-2008
Please note: The events and times on this calendar are subject to change throughout the year.
Wednesday, October 31, Richard Wise, University College London
1-2pm SSPA 22112
Friday, November 2 Chris Habeck, Columbia University Medical Center
2-3pm SSPA 2112
Friday, November 9 Chi-Hung Juan, National Central University, Taiwan
12-1pm, location TBA
Monday, November 19 Ed Awh, University of Oregon
4-5pm SSPA 2112
Friday, November 30 Quarterly Meeting
2-3pm SSPA 2112
Monday, December 3 Tatiana Pasterak, University of Rochester Medical Center
4-5pm SSPA 2112
Friday, January 25 Lunch Seminar
12-1pm, speaker and location TBA
Friday, February 8 Quarterly Meeting
2-3pm, location TBA
Friday, March 14 David Eagleman, Baylor College of Medicine
12-1pm Herklotz
Friday, April 18 Quarterly Meeting
2-3pm, location TBA
Friday, May 30 Lunch Seminar
12-1pm Speaker and location TBA
CCNS welcomes two new faculty members: Brewer and Krichmar
CCNS welcomes new members, Alyssa Brewer and Jeffrey Krichmar!
Alyssa Brewer
Assistant Professor, Cognitive Sciences
Brewer is a visual neuroscientist who focuses on the use of brain imaging and behavioral research to gain a better understanding of the organization and functions of the brain related to eyesight. Her research has been widely published in multiple peer-reviewed journals.
Brewer attended Stanford University where she received a B.A in comparative literature, a B.S. in biological science, a Ph.D. in neuroscience, and most recently, an M.D. from the School of Medicine at Stanford. She has spent the last two years working as a postdoctoral research associate at Stanford while finishing her M.D.
Jeffrey Krichmar
Assistant Professor, Cognitive Sciences
Krichmar is a computational neuroscientist whose research interests include biologically plausible models of learning and memory, the effect of neural architecture on neural function, and testing theories of the nervous system with brain-based devices that interact with the environment. Specifically, his work includes the building of robots with simulated nervous systems in order to test theoretical models of brain functions.
He received a B.S. in computer science from the University of Massachusetts at Amherst, an M.S. in computer science from George Washington University, and a Ph.D. in computational sciences and informatics from George Mason University, after which he spent 15 years as a software engineer on projects ranging from the PATRIOT Missile System at the Raytheon Corporation to Air Traffic Control for the Federal Systems Division of IBM. He later became an assistant professor at the Krasnow Institute for Advanced Study at George Mason University. Most recently, he was a senior research fellow in Theoretical Neurobiology at the Neurosciences Institute in San Diego.
Alyssa BrewerAssistant Professor, Cognitive Sciences
Brewer is a visual neuroscientist who focuses on the use of brain imaging and behavioral research to gain a better understanding of the organization and functions of the brain related to eyesight. Her research has been widely published in multiple peer-reviewed journals.
Brewer attended Stanford University where she received a B.A in comparative literature, a B.S. in biological science, a Ph.D. in neuroscience, and most recently, an M.D. from the School of Medicine at Stanford. She has spent the last two years working as a postdoctoral research associate at Stanford while finishing her M.D.
Jeffrey Krichmar Assistant Professor, Cognitive Sciences
Krichmar is a computational neuroscientist whose research interests include biologically plausible models of learning and memory, the effect of neural architecture on neural function, and testing theories of the nervous system with brain-based devices that interact with the environment. Specifically, his work includes the building of robots with simulated nervous systems in order to test theoretical models of brain functions.
He received a B.S. in computer science from the University of Massachusetts at Amherst, an M.S. in computer science from George Washington University, and a Ph.D. in computational sciences and informatics from George Mason University, after which he spent 15 years as a software engineer on projects ranging from the PATRIOT Missile System at the Raytheon Corporation to Air Traffic Control for the Federal Systems Division of IBM. He later became an assistant professor at the Krasnow Institute for Advanced Study at George Mason University. Most recently, he was a senior research fellow in Theoretical Neurobiology at the Neurosciences Institute in San Diego.
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